Imidazole derivatives
AssigneeKyowa Hakko Kirin Co., Ltd.
InventorsNaoto Osakada, Mariko Osakada, Takashi Sawada, Satoshi Kaneko, Atsuko Mizutani, Noriaki Uesaka, Yoshisuke Nakasato, Keishi Katayama, Masamori Sugawara, Yushi Kitamura
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Abstract
A CB2 receptor modulator comprising an imidazole derivative represented by the general formula (I): [wherein, R1 represents optionally substituted lower alkyl or the like; R2 represents optionally substituted cycloalkyl or the like; R3 represents optionally substituted aryl or the like; and n represents an integer of 0 to 3] or a pharmaceutically acceptable salt thereof as an active ingredient, and the like are provided.
Claims2
An imidazole derivative selected from the group consisting of:
- 5-(2-tert-Butyl-1-(tetrahydropyran-4-ylmethyl)-1H-imidazol-4-yl)-N,N-diethyl-2-fluorobenzamide;
- 3-(2-tert-Butyl-1-(tetrahydropyran-4-ylmethyl)-1H-imidazol-4-yl)-N,N-diethylbenzamide;
- 3-(2-tert-Butyl-1-(tetrahydropyran-4-ylmethyl)-1H-imidazol-4-yl)-N-ethyl-N-methylbenzamide;
- 5-(2-tert-Butyl-1-(tetrahydropyran-4-ylmethyl)-1H-imidazol-4-yl)-N,N-diethylnicotinamide;
- 4-[2-tert-Butyl-1-(tetrahydropyran-4-ylmethyl)-1H-imidazol-4-yl]-N-ethyl-N-methylthiophene-2-carboxamide;
- 6-[2-tert-Butyl-1-(tetrahydropyran-4-ylmethyl)-1H-imidazol-4-yl]-N,N-diethylpyrazine-2-carboxamide;
- 6-[2-tert-Butyl-1-(tetrahydropyran-4-ylmethyl)-1H-imidazol-4-yl]-N-methyl-N-propylpyrazine-2-carboxamide;
- 6-[2-tert-Butyl-1-(tetrahydropyran-4-ylmethyl)-1H-imidazol-4-yl]-N-ethyl-N-methylpyrazine-2-carboxamide;
- 6-[2-tert-Butyl-1-(tetrahydropyran-4-ylmethyl)-1H-imidazol-4-yl]-N,N-dimethylpyrazine-2-carboxamide;
- 6-[2-tert-Butyl-1-(4-fluorotetrahydropyran-4-ylmethyl)-1H-imidazol-4-yl]-N-ethyl-N-methylpyrazine-2-carboxamide;
- 6-[2-tert-Butyl-1-(4-fluorotetrahydropyran-4-ylmethyl)-1H-imidazol-4-yl]-N,N-dimethylpyrazine-2-carboxamide;
- and
- 5-[2-tert-Butyl-1-(tetrahydropyran-4-ylmethyl)-1H-imidazol-4-yl]-N-methyl-N-(2,2,2-trifluoroethyl)isoxazole-3-carboxamide;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.