Tetrahydroisoquinoline sulfonamide derivatives, the preparation thereof, and the use of the same in therapeutics

A method for treating a central nervous system disease selected from the group consisting of vigilance and sleep disorders, narcolepsy, Alzheimer's disease and other dementias, Parkinson's disease, attention disorders in hyperkinetic children, memory and learning disorders, epilepsy, schizophrenia, moderate cognitive disorders, depression, anxiety, sexual dysfunction, dizziness and travel sickness, said method comprising administering to a patient in need thereof an effective amount of compound of formula I:

• wherein:
• n represents a value from 1 to 6;
• —(C)n- represents a C1-6 alkylidene group optionally substituted with 1 to 4 substituents selected from halogen, hydroxyl, nitro, cyano, amino, C1-3 monoalkylamino, C2-6 dialkylamino and C1-3 alkoxy;
• R1 represents a hydrogen atom or a C1-6 alkyl group;
• R2 represents a hydrogen atom, or a C1-6 alkyl or C3-6 cycloalkyl group optionally substituted with 1 to 4 substituents selected from a halogen atom, a hydroxyl, nitro, cyano, amino, C1-3 monoalkylamino, C2-6 dialkylamino, C1-2 perhaloalkyl, C1-3 haloalkyl, C1-3 alkoxy, C3-6 cycloalkyl, a monocyclic heteroaryl, and an aryl;
• the aryl being optionally substituted with 1 to 4 substituents selected from a halogen atom, a hydroxyl, nitro, cyano, amino, C1-3 monoalkylamino, C2-6 dialkylamino, C1-3 alkyl, C1-2 perhaloalkyl, C1-3 haloalkyl, C1-3 alkoxy and a C1-3 alkylidenedioxy group;
• B represents NR3R4,
• wherein R3 and R4 represent, independently of one another, a C1-6 alkyl group, or a hydrogen atom;
• or
• R3 and R4 together represent a C1-6 alkylidene group, a C2-8 alkenylidene group, a C1-3 alkylidene-O—C1-3 alkylidene group, or a C1-3 alkylidene-N(R5)-C1-3 alkylidene group where R5 represents a hydrogen atom, or a C1-3 alkyl or C1-6 alkylcarbonyl group, it being possible for these C1-3 alkyl and C1-6 alkylcarbonyl groups to be substituted with a halogen atom, or a hydroxyl, C1-3 alkoxy, nitro, cyano or amino group;
• or
• B represents an aminocycle, linked via a carbon to the group —NR1-(C)n-, said aminocycle being selected from aziridine, azetidine, pyrrolidine, piperidine and morpholine;
• the groups R3 and R4 and also the aminocycle being optionally substituted with 1 to 4 substituents selected from a phenyl, a benzyl, a halogen, a hydroxyl, a nitro, cyano, amino, C1-3 monoalkylamino, C2-6 dialkylamino, C1-3 alkyl and C1-3 alkoxy group;
• the nitrogen atom being optionally substituted with a C1-3 alkyl;
• or a salt, a hydrate or a solvate thereof;
• with the exclusion of the compound in which R1 and R2 represent hydrogen atoms, B represents a dimethylamino group and —(C)n- represents an ethylidene group.