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US 8,273,725 B2Granted
Stable hyaluronan/steroid formulation
AssigneeGenzyme Corporation
InventorsGrace Chang, Elizabeth Voschin, Li-Ping Yu, Eugene Skrabut
Life of this patent
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Abstract
A pharmaceutical composition comprising in admixture a hyaluronic acid related component (HARC) and a pharmaceutically effective amount of triamcinolone hexacetonide (TAH). The composition is stable in an accelerated shelf life test in which the composition is heated to 80° C. for 24 hours.
Claims14
A pharmaceutical composition comprising in admixture
- a hyaluronic acid related component (HARC) and
- a pharmaceutically effective amount of triamcinolone hexacetonide (TAH),
- said composition exhibiting both following characteristics when compared in an accelerated shelf-life test to a control composition having said HARC but lacking TAH, said accelerated shelf-life test comprising heating at 80° C. for 24 hours:
- a) the change in the elastic modulus (ΔG′) of the composition is no more than 10% greater than ΔG′ of the control composition;
- b) the change in the viscosity (Δη) of the composition is no more than 10% greater than Δη of the control composition.
2 more elements
Dependencies are inferred from the claim text.