Topical drug delivery using phosphatidylcholine
AssigneeTransdermal Biotechnology, Inc.
InventorNicholas V. Perricone
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Abstract
The present invention relates to compositions and methods for transdermal drug delivery comprising formulating a phosphatidylcholine carrier composition containing the drug and applying the composition to the skin.
Claims10
A stable transdermal insulin composition comprising a phosphatidylcholine component, said phosphatidylcholine component comprising polyenylphosphatidylcholine-enriched phosphatidylcholine and at least one polyglycol, and forming a non-liposomal multilamellar liquid crystal carrier entrapping said insulin for transdermal delivery to dermal vasculature, wherein said multilamellar liquid crystal carrier stabilizes the insulin at room temperature, wherein said phosphatidylcholine component comprises 45% w/w phosphatidylcholine, 50% w/w polyglycol having a molecular weight of 200 and 5% w/w polyglycol having a molecular weight of 400.
A stable transdermal therapeutic composition comprising a phosphatidylcholine component, said phosphatidylcholine component comprising polyenylphosphatidylcholine-enriched phosphatidylcholine and at least one polyglycol, and forming a non-liposomal multilamellar liquid crystal carrier entrapping a therapeutic compound for transdermal delivery to dermal vasculature, wherein said multilamellar liquid crystal carrier stabilizes the therapeutic compound at room temperature, wherein said phosphatidylcholine component comprises 45% w/w phosphatidylcholine, 50% w/w polyglycol having a molecular weight of 200 and 5% w/w polyglycol having a molecular weight of 400.
Dependencies are inferred from the claim text.