Methods and compositions for treatment of cystic fibrosis
AssigneeThe Johns Hopkins University
InventorsNeeraj Vij, Pamela L. Zeitlin
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Abstract
The present invention relates to compounds and methods of inhibiting p97/valosin-containing protein and compounds and methods of inhibiting gp78, the compounds and methods being useful for the treatment of a disorder comprising a IκB/NFκB mediated chronic inflammatory response component, for example cystic fibrosis.
Claims1
A method of treating cystic fibrosis in an individual in need of such treatment, comprising the step of administering one or more inhibitors each of which is capable of reducing cellular degradation of cystic fibrosis transmembrane regulator, wherein the one or more inhibitors are selected from the group consisting of a p97/valosin-containing protein inhibitor, a gp78 inhibitor, and a proteasome inhibitor.
Dependencies are inferred from the claim text.