Modified growth hormone polypeptides
AssigneeAsterion Limited
InventorsPeter Artymiuk, Richard Ross, Jon Sayers
Life of this patent
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Abstract
We describe modified growth hormone fusion proteins and dimers comprising said fusion proteins; nucleic acid molecules encoding said proteins and methods of treatment that use said proteins in the treatment of conditions that result from growth hormone excess.
Claims22
An isolated nucleic acid molecule comprising a nucleic acid sequence selected from the group consisting of:
- the nucleic acid sequence set forth as SEQ ID NO:22;
- and the nucleic acid sequence set forth as SEQ ID NO:23.
An isolated polypeptide encoded by an isolated nucleic acid molecule comprising the nucleic acid sequence set forth as SEQ ID NO:
- 22 or SEQ ID NO:
- 23.
An isolated polypeptide comprising an amino acid sequence selected from the group consisting of:
- the amino acid sequence set forth as SEQ ID NO:24;
- and the amino acid sequence set forth as SEQ ID NO:32.
A homodimer comprising two identical polypeptides, wherein each of the two polypeptides comprises the amino acid sequence set forth as SEQ ID NO:
- 24 ;
- or SEQ ID NO:
- 32.
An isolated polynucleotide encoding a polypeptide comprising the amino acid sequence set forth as SEQ ID NO:32.
Dependencies are inferred from the claim text.