Extraction of solvents from drug containing polymer reservoirs
AssigneeCordis Corporation
InventorsVipul Dave, Robert Falotico, Jonathon Z. Zhao
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Abstract
A process for reducing solvent contents in drug-containing polymeric compositions may be utilized to reduce the solvent content in implantable medical device wherein the compositions are in reservoirs. Specifically, the solvent contents in the drug-containing polymeric compositions are first reduced by one or more conventional drying methods, to a range from about 0.5 weight percent to about 10 weight percent of the total weight of the polymeric composition. Subsequently, the drug-containing polymeric compositions are further treated by a low temperature drying method for further reduction of the solvent content.
Claims9
A method for extracting solvents from a polymeric/therapeutic agent matrix contained within reservoirs of a medical device comprising removing a majority of the solvent utilizing low temperature drying to a level of less than about 5 weight percent without performing a conventional drying method and then exposing the medical device to carbon dioxide at a pressure in the range from about sixty bar to about sixty-five bar at a temperature in the range from about twenty-five to about thirty-six degrees C. for a time period less than twenty five minutes.
Dependencies are inferred from the claim text.