Methods and compositions for administration of TRPV1 agonists
AssigneeNeurogesX, Inc.
InventorsNaweed Muhammad, Gene Curtis Jamieson, Keith R. Bley, Sanjay Chanda
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Abstract
Compositions are provided that contain a TRPV1 agonist, such as capsaicin, and a solvent system. Topical application of the composition results in rapid delivery of agonist to the dermis and epidermis. Method of using the compositions for reducing nociceptive nerve fiber function in subjects, and for treatment of capsaicin-responsive conditions are also provided.
Claims12
A method for treating a capsaicin-responsive condition in a subject comprising administering a liquid formulation to the subject, the liquid formulation comprising between about 10% (w/v) to about 30% (w/v) of a TRPV1 agonist, at least a first penetration enhancer and a second penetration enhancer, wherein the first penetration enhancer is propylene glycol or diethylene glycol monoethyl ether and the second penetration enhancer is selected from the group consisting of ethyl oleate, oleic acid, oleyl alcohol, benzyl alcohol and menthone, and optional additional components comprising not more than 5% (w/v) of the liquid formulation.
A method of treating skin cancer in a subject comprising administering a liquid formulation to the subject, the liquid formulation comprising between about 10% (w/v) to about 30% (w/v) of a TRPV1 agonist, at least a first penetration enhancer and a second penetration enhancer, wherein the first penetration enhancer is propylene glycol or diethylene glycol monoethyl ether and the second penetration enhancer is selected from the group consisting of ethyl oleate, oleic acid, oleyl alcohol, benzyl alcohol and menthone, and optional additional components comprising not more than 5% (w/v) of the liquid formulation.
Dependencies are inferred from the claim text.