Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol
AssigneeMemorial Sloan Kettering Cancer Center
InventorsRaymond P. Warrell, Jr., Pier Paolo Pandolfi, Janice L. Gabrilove
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Abstract
The invention relates to the use of arsenic compounds to treat a variety of leukemia, lymphoma and solid tumors. Further, the arsenic compounds may be used in combination with other therapeutic agents, such as a retinoid. The invention also provides a process for producing arsenic trioxide formulations.
Claims20
A method for treating a patient having a diagnosis of acute promyelocytic leukemia (APL) comprising administering to the patient a therapeutically effective amount of arsenic trioxide, wherein the diagnosis of APL in the patient involves assay for a t(15;17) chromosomal translocation or assay for expression of PML/RAR-α.
A method for treating a patient having a diagnosis of acute promyelocytic leukemia (APL) comprising administering to the patient a therapeutically effective amount of arsenic trioxide based on the body weight of the patient, wherein the diagnosis of APL in the patient involves assay for a t(15;17) chromosomal translocation or assay for expression of PML/RAR-α.
Dependencies are inferred from the claim text.