Dialysis solutions containing pyrophosphates
AssigneesBaxter International Inc., Baxter Healthcare S.A.
InventorsBruce L. Riser, Paul Zieske, Sujatha Karoor, Himanshu D. Patel
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Abstract
Dialysis solutions comprising pyrophosphates and methods of making and using the dialysis solutions are provided. In an embodiment, the present disclosure provides a dialysis solution comprising a stable and therapeutically effective amount of pyrophosphate. The dialysis solution can be sterilized, for example, using a technique such as autoclave, steam, high pressure, ultra-violet, filtration or combination thereof. The dialysis solution can be in the form of a concentrate.
Claims26
A heat sterilized solution comprising a pyrophosphate, a buffer comprising bicarbonate, and a pH greater than 7, wherein the bicarbonate buffer and the pH greater than 7 heat stabilize the pyrophosphate.
A heat sterilized dialysis product comprising:
- a first dialysis part comprising a dialysis component selected from the group consisting of osmotic agents, electrolytes and combinations thereof;
- and
- a second dialysis part comprising pyrophosphate, bicarbonate and a pH greater than 7, wherein the bicarbonate and the pH greater than 7 heat stabilize the pyrophosphate.
Dependencies are inferred from the claim text.