Multiparticle pharmaceutical dosage form for a low-soluble active substances and method for producing said pharmaceutical dosage form

A composition suitable for oral administration comprising a casing that disintegrates in a gastric pH range and that contains

• pellets, particles, granules or agglomerates that have a mean diameter ranging between 50 and 2,500 μm and comprising:
• a) an inner matrix layer comprising
• an active substance other than a peptide, protein, peptide or protein derivative, or peptide or protein conjugate,
• a lipophilic matrix with a melting point of over 37° C.;
• and
• a mucoadhesive polymer;
• and
• b) a film-applied outer coating, consisting essentially of an anionic polymer or copolymer, and, optionally, one or more pharmaceutically customary excipients,
• wherein the active substance in the inner matrix layer has a water-solubility as defined in the German Pharmacopeia DAB 10 of at least 30 parts by volume of water for 1 part by weight of the active substance,
• wherein the lipophilic matrix with its active substance is embedded in a matrix made from the mucoadhesive polymer used jointly with an acid or a buffer system which is present in the matrix or in or on a core to which the matrix is applied, which matrix comprises a chitosan and is adjusted to pH 5.0-5.5 by means of the acid or a buffer system, and is combined with a film-applied outer coating which begins to dissolve in the range of pH 6.0 to 8.0.