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US 8,273,374 B2Granted
Preservation of bioactive materials by spray drying
AssigneeMedImmune, LLC
InventorsVu Truong-Le, Binh Pham
Life of this patent
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Abstract
This invention provides methods and compositions to preserve bioactive materials in a matrix of powder particles. Methods provide high-pressure gas spraying and/or near supercritical spraying of formulations followed by drying in a stream of conditioned gas to form stable powder particles containing bioactive materials.
Claims10
Powder particles prepared by high pressure spraying, wherein the high pressure spraying comprises:
- preparing a suspension or solution comprising a bioactive material and a polyol;
- forming a mixture of the solution or suspension with a high pressure gas;
- reducing a pressure on the mixture, thereby forming a gaseous suspension of droplets;
- and,
- drying the droplets into powder particles by exchanging a gas from the gaseous suspension of droplets with a drying gas.
2 more elements
Dependencies are inferred from the claim text.