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US 8,273,373 B2Granted
Photocrosslinked biodegradable hydrogel
AssigneeCase Western Reserve University
InventorsEben Alsberg, Oju Jeon
Life of this patent
Estimating the term…
Abstract
A photocrosslinked biodegradable hydrogel includes a plurality of natural polymer macromers cross-linked with a plurality of hydrolyzable acrylate cross-links. The hydrogel is cytocompatible and produces substantially non-toxic products upon degradation.
Claims24
A photocrosslinked biodegradable hydrogel comprising:
- a plurality of saccharides cross-linked with a plurality of cross-links that are degradable in vivo, the hydrogel being cytocompatible and, upon degradation, producing substantially non-toxic products, wherein the cross-links comprise hydrolyzable acrylate cross-links selected from the group consisting of Formula I
- and Formula II
- and wherein R1 and R2 are the same or different saccharides.
A photocrosslinked biodegradable hydrogel comprising:
- a plurality of saccharides cross-linked with a plurality of hydrolyzable acrylate cross-links that can be hydrolyzed in vivo, the hydrogel being cytocompatible and, upon degradation, producing substantially non-toxic products, wherein the hydrolyzable acrylate cross-links are selected from the group consisting of Formula I
- and Formula II
- and wherein R1 and R2 are the same or different saccharides.
A method for forming a photocrosslinked biodegradable hydrogel, the method comprising:
- reacting at least one crosslinkable acryl group with at least one saccharide to form a mixture comprising a plurality of acrylated macromers, the acryl group including at least one hydrolyzable linkage;
- contacting the mixture with a photoinitiator to initiate cross-linking of the macromers;
- and
- exposing the mixture to a light source to initiate cross-linking of the macromers and thereby form a plurality of saccharides cross-linked with a plurality of hydrolyzable acrylate cross-links selected from the group consisting of Formula I
- and Formula II
- and wherein R1 and R2 are the same or different saccharides.
3 more elements
A method for promoting tissue growth in a subject comprising:
- administering a photocrosslinked biodegradable hydrogel to a target site in the subject, the hydrogel comprising a plurality of saccharides cross-linked with a plurality of hydrolyzable acrylate cross-links and at least one cell dispersed on or within the hydrogel, the hydrogel being cytocompatible and producing substantially non-toxic products upon degradation, wherein the hydrolyzable acrylate cross-links are selected from the group consisting of Formula I
- and Formula II
- and wherein R1 and R2 are the same or different saccharides.
Dependencies are inferred from the claim text.