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US 8,273,365 B2Granted
Two-piece, internal-channel osmotic delivery system flow modulator
AssigneeIntarcia Therapeutics, Inc.
InventorsScott D. Lautenbach, Pedro E. de la Serna, Pauline C. Zamora, Michael A. DesJardin
Life of this patent
Estimating the term…
Abstract
An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening, an inner core inserted in the outer shell, and a fluid channel having a spiral shape defined between the outer shell and the inner core. The fluid channel is adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system.
Claims20
An implantable delivery system for an active agent formulation, comprising:
- a reservoir made of an impermeable, metallic material;
- a partition within the reservoir, the partition defining within the reservoir a first chamber and a second chamber;
- the first chamber in the reservoir containing an osmotic engine;
- the second chamber in the reservoir containing the active agent formulation;
- a semipermeable plug disposed at a first end of the reservoir adjacent the first chamber;
- and
- a flow modulator comprising (i) two pieces, an outer shell and an inner core, and (ii) an internal fluid channel, the flow modulator disposed at a second end of the reservoir adjacent the second chamber, the flow modulator comprising
- the outer shell positioned in an opening at the second end of the reservoir, the outer shell comprising an inner surface,
- the inner core inserted in the outer shell, the inner core comprising an outer surface, and
- the internal fluid channel having a spiral shape defined between the outer shell and the inner core, wherein the outer shell and the inner core are made of a non-metallic material.
7 more elements
A method of making an implantable delivery system for an active agent formulation, comprising:
- positioning a piston within a reservoir, the piston defining within the reservoir a first chamber and a second chamber, wherein the reservoir is made of an impermeable, metallic material;
- positioning an osmotic engine within the first chamber;
- positioning a semipermeable plug in a first opening at a first end of a reservoir, adjacent the osmotic engine;
- filling the second chamber with the active agent formulation;
- and
- positioning a flow modulator in a second opening at a second end of the reservoir adjacent the active agent formulation, the flow modulator comprising
- an outer shell positioned in the opening at the second end of the reservoir, the outer shell comprising an inner surface,
- an inner core inserted in the outer shell, the inner core comprising an outer surface, and
- a fluid channel having a spiral shape defined between the outer shell and the inner core, wherein the outer shell and the inner core are made of a non-metallic material.
6 more elements
Dependencies are inferred from the claim text.