Outer membrane vesicle (OMV) vaccine comprising N. meningitidis serogroup B outer membrane proteins
AssigneeNovartis AG
InventorsMariagrazia Pizza, Rino Rappuoli, Marzia Monica Giuliani
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Abstract
A composition comprising (a) Neisseria meningitidis serogroup B outer membrane vesicles (OMVs), and (b) an immunogenic component selected from other Neisseria proteins, or immunogenic fragments thereof. Component (b) preferably includes a protein from a different NmB strain from that from which the OMV of component (a) is derived. The OMVs are preferably obtained by deoxycholate extraction. Optionally, the composition may also comprise a protective antigen against other pathogens.
Claims17
A composition comprising a Neisseria meningitidis serogroup B outer membrane preparation mixed with a purified m741.pep protein comprising the amino acid sequence of SEQ ID NO:
- 22 or an immunogenic fragment of the m741.pep protein comprising ten or more consecutive amino acids of the amino acid sequence of SEQ ID NO:
- 22.
A composition comprising a Neisseria meningitidis serogroup B outer membrane preparation isolated from a recombinant serogroup B Neisseria meningitidis that hyperproduces a protein from a strain of Neisseria meningitidis serogroup B different from the recombinant serogroup B Neisseria meningitidis and wherein the protein is m741.pep comprising the amino acid sequence of SEQ ID NO:
- 22 or an immunogenic fragment of the m741.pep protein comprising ten or more consecutive amino acids of the amino acid sequence of SEQ ID NO:
- 22.
Dependencies are inferred from the claim text.