Anti-RSV G protein antibodies

An isolated mAb or immunoreactive fragment thereof wherein

• the heavy chain has a CDR1 region consisting of SSNYYWG (positions 31-37 of SEQ ID NO:29), a CDR2 region consisting of SIHDSGSIYYNPSLRS (positions 52-67 of SEQ ID NO:29), and a CDR3 region consisting of HLVWFGELRNNWFDP (positions 100-114 of SEQ ID NO:29) and the light chain has a CDR1 region consisting of RASQSVNSNLA (positions 24-34 of SEQ ID NO:43), a CDR2 region consisting of GASTRAT (positions 50-56 of SEQ ID NO:43), and a CDR3 region consisting of QQYNNWPL (positions 89-96 of SEQ ID NO:43) (3G12), or
• the heavy chain has a CDR1 region consisting of EHAMH (positions 31-35 of SEQ ID NO:31), a CDR2 region consisting of GISWNSGSVGYADSVKG (positions 50-66 of SEQ ID NO:31), and a CDR3 region consisting of MVATTKNDFHYYKDV (positions 99-113 of SEQ ID NO:31) and the light chain has a CDR1 region consisting of KASQSVSNHLA (positions 24-34 of SEQ ID NO:45), a CDR2 region consisting of ETSNRAT (positions 50-56 of SEQ ID NO:45), and a CDR3 region consisting of QQRNNWYT (positions 89-96 of SEQ ID NO:45) (3D3), or
• the heavy chain has a CDR1 region consisting of TYPIS (positions 31-35 of SEQ ID NO:33), a CDR2 region consisting of RIIPDPPMANIAQKFQG (positions 50-66 of SEQ ID NO:33), and a CDR3 region consisting of EILQSPPFAVDV (positions 99-110 of SEQ ID NO:33) and the light chain has a CDR1 region consisting of TGSSSDVGGYSHVS (positions 23-36 of SEQ ID NO:47), a CDR2 region consisting of EVSNRPS (positions 52-58 of SEQ ID NO:47), and a CDR3 region consisting of GSYASTNILH (positions 91-100 of SEQ ID NO:47) (2B11), or
• the heavy chain has a CDR1 region consisting of TYYIH (positions 31-35 of SEQ ID NO:37), a CDR2 region consisting of VINPSGGSTTYAQKFQD (positions 50-66 of SEQ ID NO:37), and a CDR3 region consisting of VHKGRAEQWQLLHGHFDL (positions 99-116 of SEQ ID NO:37) and the light chain has a CDR1 region consisting of KSSQSVLYSSNNKTYLA (positions 24-40 of SEQ ID NO:51), a CDR2 region consisting of WASTRES (positions 56-62 of SEQ ID NO:51), and a CDR3 region consisting of QQYYTTP (positions 95-101 of SEQ ID NO:51) (1D4), or
• the heavy chain has a CDR1 region consisting of SGQYYWA (positions 31-37 of SEQ ID NO:38), a CDR2 region consisting of SIHYSGSTYQNPSLKS (positions 52-67 of SEQ ID NO:38), and a CDR3 consisting of region QQLSLSPVENWFDP (positions 100-113 of SEQ ID NO:38) and the light chain has a CDR1 region consisting of RASRSVGSRLA (positions 24-34 of SEQ ID NO:52), a CDR2 region consisting of AASTRAT (positions 50-56 of SEQ ID NO:52), and a CDR3 region consisting of QQYKEWPL (positions 89-96 of SEQ ID NO:52) (IG8), or
• the heavy chain has a CDR1 region consisting of GYAMH (positions 31-35 of SEQ ID NO:40), a CDR2 region consisting of VISFDGSNNYYADSVKG (positions 50-66 of SEQ ID NO:40), and a CDR3 region consisting of PDVIAVAGTALSNPFDL (positions 99-115 of SEQ ID NO:40) and the light chain has a CDR1 region consisting of RASQSVRSNLV (positions 23-33 of SEQ ID NO:54), a CDR2 region consisting of GASTRAT (positions 49-55 of SEQ ID NO:54), and a CDR3 region consisting of QQNNNWPP (positions 87-95 of SEQ ID NO:54) (1006).