Anti-virus therapy for respiratory diseases
AssigneeUniversity of Southampton
InventorsDonna Elizabeth Davies, Peter Alexander Blanch Wark, Stephen Holgate, Sebastian L. Johnston
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Abstract
The present invention provides the use of IFN-β, an agent that increases the expression of IFN-β, or a polynucleotide which is capable of expressing IFN-β or said agent for the manufacture of a medicament for the treatment of rhinovirus-induced exacerbation of a respiratory disease selected from asthma and chronic obstructive pulmonary disease, wherein said treatment is by airway delivery of said medicament, e.g. by use of an aerosol nebulizer. Also provided is IFN-λ for the same purpose.
Claims8
A method of treating in an individual a rhinovirus-induced exacerbation of a respiratory disease selected from asthma and COPD, comprising administering to the lower respiratory tract an agent selected from the group consisting of:
- (a) an agent that increases interferon-β (IFN-β) expression;
- or
- (b) a polynucleotide which is capable of expressing such an agent or IFN-β,
- wherein the administration results in suppression of rhinovirus replication in the individual.
Dependencies are inferred from the claim text.