US 8,273,341 B2 · Antiviral compounds

Antiviral compounds

AssigneeGilead Sciences, Inc.

InventorsHongyan Guo, Darryl Kato, Thorsten A. Kirschberg, Hongtao Liu, John O. Link, Michael L. Mitchell, Jay P. Parrish, Michael Graupe, Jianyu Sun, James Taylor, Elizabeth M. Bacon, Eda Canales, Aesop Cho, Choung U. Kim, Jeromy J. Cottell, Manoj C. Desai, Randall L. Halcomb, Evan S. Krygowski, Scott E. Lazerwith, Qi Liu, Richard Mackman, Hyung-Jun Pyun, Joseph H. Saugier, James D. Trenkle, Winston C. Tse, Randall W. Vivian, Scott D. Schroeder, William J. Watkins, Lianhong Xu

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Abstract

The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Claims21

Dependent claims

A method of inhibiting HCV in a human comprising administering a compound of formula:

wherein:
V is alkyl;
L is benzimidazolyl;
M is a 5-membered heteroaryl ring;
A15 is:
and
P is selected from:
or a pharmaceutically acceptable salt, or prodrug thereof to the human.

5 more elements

Dependencies are inferred from the claim text.

Facts

Application

13/291,977Filed 8 Nov 2011 · division

Priority

13 May 2009

Published

US 2012/0157404 A121 Jun 2012

Granted

25 Sep 2012

Term ends

Not estimatedThe source records don’t support an estimate.

Classification34 codes

C07D 403/14
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group…
A61K 31/4025
Having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil: not condensed and…
A61K 31/4178
1,3-Diazoles: not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
A61K 31/4184
1,3-Diazoles: condensed with carbocyclic rings, e.g. benzimidazoles

Family

Application61/177,972Us provisional application · filed 13 May 2009

Application61/224,745Us provisional application · filed 10 Jul 2009

Application61/238,760Us provisional application · filed 1 Sep 2009

Application12/779,023Parent of this division · filed 12 May 2010

US 2012/0157404 A1Pre-grant publication · published 21 Jun 2012

US 8,088,368 B2Parent of this division

US 2010/0310512 A1Published application

US 8,273,341 B2This patent

From the US filing history. Foreign family members aren’t listed.