Inhalation compositions
AssigneeNorton Healthcare Limited
InventorXian-Ming Zeng
Life of this patent
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Abstract
The invention provides a dry powder inhalation composition comprising medicament particles and a mixture of lactose particles with a VMD of between about 70 and about 120 microns and a diameter of less than 250 microns, the mixture being characterized in that up to 96% by weight of the lactose particles are less than 150 microns in diameter and wherein up to 25% by weight of the lactose particles are less than 5 microns in diameter. The compositions provide for a more accurate, uniform and consistent dispersion when used with, for example, a multidose dry powder inhaler. Also disclosed are methods for use of the compositions of the invention.
Claims15
A dry powder inhalation composition comprising,
- (a) medicament particles, and
- (b) a mixture of lactose particles with a volume mean diameter (VMD) of between about 70 and about 120 microns and a diameter of less than 250 microns, wherein up to 96% by weight of the lactose particles are less than 150 microns in diameter and wherein up to 25% by weight of the lactose particles are less than 5 microns in diameter.
A dry powder inhalation composition comprising,
- (a) medicament particles, and
- (b) a mixture of lactose particles characterized by the particle size distribution of the following table
- % Cumulative Undersize
- Size/gm
- Target
- Range
- <10
- 11.0
- 8-13.5
- <30
- 17.5
- 10-25
- <60
- 31.0
- 20-42
- <90
- 45.0
- 30-60
- <174
- >90
- —
- <250
- 100
- —
Dependencies are inferred from the claim text.