# US 8,273,104 B2 · Antimicrobial sutures and methods of making them

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- Number: US 8,273,104 B2
- Document ID: US8273104B2
- Status: Granted
- Kind: B2
- Application number: 11/485,591
- Filed: 2006-07-11
- Published: 2007-01-11
- Granted: 2012-09-25
- Earliest claimed: 2005-07-11
- Assignees: Tyco Healthcare Group LP
- Inventors: Matthew Cohen
- Web page: https://patentgrep.com/patent/US8273104B2

## CPC

- A61L 17/005: {containing a biologically active substance, e.g. a medicament or a biocide}
- A61L 17/14: Post-treatment to improve physical properties
- A61L 17/145: {Coating}
- A61L 2300/202: with halogen atoms, e.g. triclosan, povidone-iodine
- A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents
- A61L 2300/606: Coatings
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

Multifilament sutures are prepared by permeating the suture with an antimicrobial solution and applying an antimicrobial coating to the suture.

## Claims

### Claim 1

A method comprising:
providing a multifilament suture;
permeating the multifilament suture with an antimicrobial solution; and
applying an antimicrobial coating containing about 5% to about 25% of an antimicrobial agent and from about 10 percent to about 20 percent of one or more fatty acid components onto at least a portion of the surface of the permeated multifilament suture.

### Claim 2 (depends on 1)

The method of claim 1 wherein the antimicrobial solution comprises at least one antimicrobial agent selected from the group consisting of antibiotics, antiseptics, disinfectants and combinations thereof.

### Claim 3 (depends on 1)

The method of claim 1 wherein the antimicrobial solution comprises triclosan.

### Claim 4 (depends on 1)

The method of claim 1 wherein the antimicrobial solution comprises at least one solvent selected from the group consisting of alcohols, ketones, ethers, aldehydes, acetonitrile, acetic acid, methylene chloride, chloroform and water.

### Claim 5 (depends on 1)

The method of claim 1 wherein the antimicrobial coating comprises at least one antimicrobial agent and at least one film-forming polymer.

### Claim 6 (depends on 1)

The method of claim 1 wherein the antimicrobial coating comprises at least one antimicrobial agent selected from the group consisting of antibiotics, antiseptics, disinfectants and combinations thereof.

### Claim 7 (depends on 1)

The method of claim 1 wherein the antimicrobial coating comprises triclosan.

### Claim 8 (depends on 1)

The method of claim 1 wherein the antimicrobial coating comprises at least one film-forming polymer that contains linkages derived from one or more monomers selected from the group consisting of glycolide, lactide, caprolactone, trimethylene carbonate, dioxanones and dioxepanones.

### Claim 9 (depends on 1)

The method of claim 1 wherein the antimicrobial coating comprises a glycolide/caprolactone copolymer as the film-forming polymer.

### Claim 10 (depends on 1)

The method of claim 1 wherein the one or more fatty acid components are selected from the group consisting of fatty acids, fatty acid salts and fatty acid esters.

### Claim 11 (depends on 1)

The method of claim 1 wherein the one or more fatty acid components comprises at least one salt of a fatty acid ester selected from the group consisting of magnesium stearoyl lactylate, aluminum stearoyl lactylate, barium stearoyl lactylate, zinc stearoyl lactylate, calcium palmityl lactylate, magnesium palmityl lactylate, aluminum palmityl lactylate, barium palmityl lactylate, zinc palmityl lactylate, calcium olelyl lactylate, magnesium olelyl lactylate, aluminum olelyl lactylate, barium olelyl lactylate, zinc olelyl lactylate, and calcium stearoyl lactylate.

### Claim 12 (depends on 1)

The method of claim 1 wherein the one or more fatty acid components is calcium stearoyl lactylate.