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US 8,268,886 B2Granted
Pyrenyloxysulfonic acid fluorescent agents
AssigneeLife Technologies Corporation
InventorsRichard Haugland, Wai-Yee Leung, Jixiang Liu
Life of this patent
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Abstract
The invention provides a novel class of reactive fluorescent agents that are based on a pyrene sulfonic acid nucleus. The agents are readily incorporated into conjugates with other species by reacting the reactive group with a group of complementary reactivity on the other species of the conjugate. Also provided are methods of using the compounds of the invention to detect and/or quantify an analyte in a sample. In an exemplary embodiment, the invention provides multi-color assays incorporating the compounds of the invention.
Claims37
A compound having structure VI:
- wherein
- designates a linker arm covalently attached to a reactive group;
- and
- s and t are independently selected from the integers from 0 to 3, with the proviso that at least one of s and t is at least 1.
1 more element
A compound having structure VI:
- wherein
- s is 1;
- t is 2;
- and
- is a linker arm and the linker arm is covalently attached to a reactive group having the structure:
2 more elements
Dependencies are inferred from the claim text.