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US 8,268,882 B2Granted
Triptolide C-ring derivatives as anticancer agents and immune modulators
AssigneePharmagenesis, Inc.
InventorJohn H. Musser
Life of this patent
Estimating the term…
Abstract
Disclosed are compounds based on C- and D-ring modifications of triptolide and hydroxylated triptolide, for use in therapy, such as antiproliferative, anticancer, and immunosuppressive therapy.
Claims14
A compound having the structure I:
- where
- each of R1, R2, R3, and R4 is independently selected from hydrogen, hydroxy —O(CO)nX, —O(CO)nOR5, and —O(CO)nN(R5)2, where X is halogen, R5 is hydrogen or lower alkyl, and n is 1-2,
- with the proviso that at least three of R1, R2, R3, and R4 are hydrogen;
- m is 1-2;
- X2 is halogen;
- and
- X1 is halogen and W is hydroxyl, or X1 and W together form an epoxy group.
4 more elements
A compound having the structure II:
- where
- each, R1, R2, R3, and R4 is independently selected from hydrogen, hydroxyl, —O(CO)nX, —O(CO)nOR5, and —O(CO)nN(R5)2, where X is halogen, R5 is hydrogen or lower alkyl, and n is 1-2, with the proviso that at least three of R1, R2, R3, and R4 are hydrogen;
- and p is 0-4.
Dependencies are inferred from the claim text.