Compositions and methods for identification of PARP function, inhibitors, and activators

A solid surface comprising at least four discrete locations, the at least four discrete locations comprising a different PARP fusion protein from one another, the PARP fusion proteins encoded by 4 or more nucleic acid sequences comprising:

• (a) a PARP sequence at least 95% identical to a PARP selected from PARP1 (SEQ ID NOs:
• 1 or 2), PARP2 (SEQ ID NO:
• 3), PARP3 (SEQ ID NO:
• 4), PARP3 isoform 2 (PARP3.2;
• SEQ ID NO:
• 5), PARP3 isoform 3 (PARP3.3;
• SEQ ID NO:
• 6), PARP4 (SEQ ID NO:
• 7), PARP5a (Tankyrase 1)(SEQ ID NO:
• 8 or 9), PARP5b (Tankyrase 2) (SEQ ID NO:
• 10), PARP6 (SEQ ID NO:
• 11), PARP7 (SEQ ID NO:
• 12), PARP8 (SEQ ID NO:
• 13), PARP9 (SEQ ID NO:
• 14), PARP10 (SEQ ID NO:
• 15), PARP 10.2 (SEQ ID NO:
• 16), PARP11 (SEQ ID NO:
• 17), PARP12 (SEQ ID NO:
• 18), PARP13 isoform 1 (PARP13.1;
• SEQ ID NO:
• 19), PARP13 isoform 2 (PARP13.2;
• SEQ ID NO:
• 20), PARP14 (SEQ ID NO:
• 21), PARP15 isoform 1 (PARP15.1;
• SEQ ID NO:
• 22), PARP15 isoform 2 (PARP15.2;
• SEQ ID NO:
• 23), and PARP16 (SEQ ID NO:
• 24);
• and
• (b) a polypeptide tag sequence.