Particle analysis in an acoustic cytometer
AssigneeLos Alamos National Security, LLC
InventorsGregory Kaduchak, Michael D. Ward
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Abstract
The present invention is a method and apparatus for acoustically manipulating one or more particles. Acoustically manipulated particles may be separated by size. The particles maybe flowed in a flow stream and acoustic radiation pressure, which may be radial, may be applied to the flow stream. This application of acoustic radiation pressure may separate the particles. In one embodiment, the particles may be separated by size, and as a further example, the larger particles may be transported to a central axis.
Claims24
An apparatus that separates particles by size comprising:
- a capillary for flowing a fluid containing the particles therein;
- and
- a radial acoustic signal producing transducer acoustically separating the particles in said capillary by size by applying radial acoustic pressure to the particles, wherein smaller particles are substantially unaffected by the radial acoustic signal producing transducer.
An apparatus that separates particles by size comprising:
- a capillary for flowing a fluid containing the particles therein, the particles comprising larger particles and smaller particles;
- and
- a radial acoustic signal producing transducer acoustically separating the particles in said capillary by size by applying radial acoustic pressure to the particles, wherein smaller particles comprise cellular debris.
An apparatus that separates particles by size comprising:
- a capillary for flowing a fluid containing the particles therein, the particles comprising larger particles and smaller particles;
- and
- a radial acoustic signal producing transducer acoustically separating the particles in said capillary by size by applying radial acoustic pressure to the particles, wherein the smaller particles comprise proteins.
Dependencies are inferred from the claim text.