Devices and methods for treatment of heart failure and associated conditions

A method, comprising:

• causing a baroreflex therapy system to be manufactured and made available to a user, the baroreflex therapy system configured to be implantable within a patient;
• causing an implantable measurement device to be manufactured and made available to the user, the implantable measurement device configured to be implantable proximate a blood vessel of the patient, the implantable measurement device including a plurality of electrodes;
• causing a control system to be manufactured and made available to the user, the control system configured to be coupled to the baroreflex therapy system and the implantable measurement device;
• and
• programming the control system with instruction recorded on a tangible medium for operating the control system to deliver a therapy to treat heart failure, the instructions comprising:
• determine an impedance of the blood vessel with the implantable measurement device over a time period of at least one cardiac cycle;
• generate at least one signal representative of a pressure waveform based on the impedance;
• activate, deactivate or otherwise modulate the baroreflex therapy system to deliver a therapy to treat heart failure based at least in part on the at least one signal representative of the pressure waveform.

A system, comprising:

• an implantable baroreflex activation device;
• an implantable measurement device configured to be implanted proximate a blood vessel of a patient, the implantable measurement device including a plurality of electrodes;
• and
• a control system coupled to the baroreflex activation device and the implantable measurement device, the control system programmed to automatically:
• determine an impedance of the blood vessel with the implantable measurement device over a time period of at least one cardiac cycle;
• generate at least one signal representative of a pressure waveform based on the impedance;
• activate, deactivate or otherwise modulate the baroreflex therapy system to deliver a therapy to treat heart failure based at least in part on the at least one signal representative of the pressure waveform.