US 8,264,245 B2Granted

Device and system for measuring properties of cells and method of measuring properties of cells using the same

AssigneeSamsung Electro-Mechanics Co., Ltd.

InventorsBo Sung Ku, Tae Yoon Kim, Young-Ho Cho, Young Soo Oh, Sung Koo Kang, Sang Jin Kim

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Abstract

According to a device and system for measuring the properties of cells, there is an advantage in that, since a cell accommodation unit having a volume is provided, the properties of three-dimensional cells can be measured. Further, the present invention is advantageous in that it enables passive measurement of multiple properties which passively measures the electrical, mechanical and/or optical properties of cells, and active measurement of multiple properties which actively applies electrical, mechanical and optical types of stimulation to cells and measures their electrical, mechanical and/or optical reactions, thus measuring the multiple properties of cells with high reliability.

Claims22

Dependent claims

A device for measuring properties of cells, comprising:

a well including a cell accommodation unit connected to an inlet and an outlet, and a first electrode accommodation unit and a second electrode accommodation unit arranged with the cell accommodation unit disposed therebetween;
an electrical property measurement unit including a first electrode formed in the first electrode accommodation unit and a second electrode formed in the second electrode accommodation unit so as to measure electrical properties of cells accommodated in the cell accommodation unit and/or apply electrical stimulation to the cells;
and
electric field connection channels formed between the first electrode accommodation unit and the cell accommodation unit and between the second electrode accommodation unit and the cell accommodation unit, and configured to control a pattern of electric fields in the cell accommodation unit in three dimensions by adjusting angles of the electric field connection channels;
wherein the well further includes a mechanical property measurement unit arranged either above or below or both above and below the cell accommodation unit and configured to measure mechanical properties of the cells and/or to apply mechanical stimulation to the cells.

2 more elements

A method of measuring properties of cells, comprising:

(A) providing a device for measuring properties of cells, the device including a cell accommodation unit connected to an inlet and an outlet and configured to accommodate cells and have a volume, an electrical property measurement unit, a mechanical property measurement unit, and/or an optical property measurement unit;
(B) supplying cells into the cell accommodation unit of the cell property measurement device;
and
(C) collectively measuring mechanical, electrical and/or optical properties of the cells;
wherein the mechanical property measurement unit includes a membrane actuating channel formed either above or below or both above and below the cell accommodation unit and a membrane disposed between the membrane actuating channel and the cell accommodation unit so as to isolate the membrane actuating channel from the cell accommodation unit;
the membrane includes a plurality of membrane units that are independently or dependently actuated;
and
the mechanical stimulation is common membrane stimulation applied to the entire membrane, individual membrane stimulation individually applied to respective membrane units, or a combination thereof.

5 more elements

Dependencies are inferred from the claim text.