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US 8,263,822 B2Granted
TREM-2 gene and protein as inhibitors of expression of GA733-2, and transgenic animals comprising the same and uses thereof
AssigneeGlo Biotech
InventorsHyung-Sik Kang, Eun-Mi Kim, Dong-Hern Kim, Ha-Rim Choi, Eun-Hee Lee, Il-Soo Kim, Chang-Eon Park
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Abstract
Disclosed are a composition for inhibiting the expression of GA733-2 or for detecting GA733-2, which comprises TREM-2 gene or protein, a transgenic animal containing same, and a method using the same.
Claims3
A transgenic mouse whose genome comprises a recombinant DNA sequence encoding TREM-2 protein operably linked to a promoter,
- wherein the transgenic mouse exhibits decreased expression of GA733-2 mRNA in cells of thymus, Peyer's patches and lamina propria lymphocytes as compared to a wild type mouse.
A method of screening a suppressive or therapeutic agent for colon cancer, which comprises;
- administering a candidate suppressive or therapeutic agent for colon cancer to a transgenic mouse whose genome comprises a recombinant DNA sequence encoding TREM-2 protein operably linked to a promoter, wherein the transgenic mouse exhibits decreased expression of GA733-2 mRNA in cells of thymus, Peyer's patches and lamina propria as compared to a wild-type mouse;
- and
- monitoring an effect of the candidate agent on expression of GA733-2 mRNA in Peyer's patches;
- and
- selecting the candidate agent inhibiting expression of GA733-2 mRNA,
- wherein the selected agent is a potential suppressive or therapeutic agent for colon cancer.
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Dependencies are inferred from the claim text.