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US 8,263,784 B2Granted
Method for the synthesis of a ramipril intermediate
AssigneeDSM Sinochem Pharmaceuticals Netherlands B.V.
InventorsBen De Lange, Dennis Heemskerk
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Abstract
The present invention relates to a process for the preparation of octahydrocyclopenta[b]pyrrole-2-carboxylic acid and esters thereof of general formula (1) in the presence of a cobalt and/or nickel comprising catalyst and to the use of compounds of general formula (1) in the synthesis of ramipril.
Claims5
A method for the preparation of a compound of general formula (1),
- wherein R1 is hydrogen or a carboxylic acid protecting group, comprising hydrogenation of a compound of general formula (3),
- wherein R1 is as described above, in the presence of a catalyst which comprises cobalt and/or nickel.
A method for the preparation of a compound of general formula (1),
- wherein R1 is alkenyl or substituted alkenyl, alkyl or substituted alkyl, alkylcarbonyl or substituted alkylcarbonyl, aryl or substituted aryl, arylcarbonyl or substituted arylcarbonyl, silyl or substituted silyl, sulfonyl or substituted sulfonyl, comprising hydrogenation of a compound of general formula (3),
- wherein R1 is as described above, in the presence of a catalyst which comprises cobalt and/or nickel.
Dependencies are inferred from the claim text.