Insulin-regulated aminopeptidase (IRAP) inhibitors and uses thereof

A compound of Formula (I)

• wherein:
• A is pyridyl which may be optionally substituted;
• R1 is NHCOR8;
• X is O;
• R8 is selected from hydrogen, optionally substituted alkyl and optionally substituted aryl;
• R2 is CN, CO2R9, C(O)O(O)R9, C(O)R9 or C(O)NR9R10 wherein R9 and R10 are independently selected from alkyl, alkenyl, alkynyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, each of which may be optionally substituted, and hydrogen;
• or R9 and R10, together with the nitrogen atom to which they are attached, form a 3-8-membered ring which may be optionally substituted;
• R3-R6 are independently selected from hydrogen, halo, nitro, cyano alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclyl, carbocyclyl, hydroxy, alkoxy, alkenyloxy, alkynyloxy, alkynyloxy, aryloxy, heteroaryloxy, heterocyclyloxy, amino, acyl, acyloxy, carboxy, carboxyester, methylenedioxy, amido, thio, alkylthio, alkenylthio, alkynylthio, arylthio, heteroarylthio, heterocyclylthio, carbocyclylthio, acylthio and azido, each of which may be optionally substituted where appropriate, or any two adjacent R3-R6, together with the atoms to which they are attached, form a 3-8-membered ring which may be optionally substituted;
• and
• Y is hydrogen or C1-10alkyl,
• or a pharmaceutically acceptable salt thereof.