Back to results
US 8,263,767 B2Granted
AZA-indoles and related compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
AssigneeAllergan, Inc.
InventorsHaiqing Yuan, Richard L. Beard
Life of this patent
Estimating the term…
Abstract
The present invention provides compounds are disclosed herein having the formula: Wherein n is 1 or 2; m is 0 or 1; R1 is aryl, heteroaryl or alkyl; R2 is C1-6 hydrocarbyl, alkylacyl or hydroxyalkyl; R3 is aryl, heteroaryl, or alkyl; R4 is H, OH, —O—(C1-6 alkyl), —NH—(C1-6 alkyl), or oxide; R5 is H, halogen, C1-6 alkyl, O—(C1-6 alkyl), aryl, heteroaryl, —C(═O)(C1-6 alkyl), substituted or un-substituted oxazolin-2-yl; X=O, NH, —C(═O)— or —N═CH—; and Each L is independently alkylene and carbonyl.
Claims9
A compound having the formula:
- wherein n is 2 and indicates the number of enchained nitrogen atoms in the condensed 6 member ring;
- m is 0 or 1;
- R1 is aryl, heteroaryl or alkyl;
- R2 is selected from the group consisting of C1-6 hydrocarbyl, alkylacyl and hydroxyalkyl;
- R3 is selected from the group consisting of aryl, heteroaryl, or alkyl;
- R4 is H, OH, —O—(C1-6 alkyl), —NH—(C1-6 alkyl), and oxide;
- R5 is selected from the group consisting of H, halogen, C1-6 alkyl, O—(C1-6 alkyl), aryl, heteroaryl, —C(═O)(C1-6 alkyl), substituted and un-substituted oxazolin-2-yl;
- X is selected from the group consisting of O, NH, —C(═O)— and —N═CH—;
- and
- L is selected from the group consisting of alkylene, and carbonyl;
- Nitrogen atoms are not present on the bridge.
8 more elements
Dependencies are inferred from the claim text.