Promiscuous HER-2/Neu CD4 T cell epitopes
AssigneeDendreon Corporation
InventorsJami B. Wollan, Lori A. Jones
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Abstract
The present invention relates to the discovery of novel T cell epitopes of the human HER-2/Neu protein that is promiscuous for at least 25 different HLA-DR alleles. The invention also relates to compositions that contain one of the novel epitopes or a fusion peptide of such a epitope and a heterologous polypeptide. Further disclosed herein is the use of the epitopes or their fusion peptides, and compositions containing the epitopes or their fusion peptides.
Claims12
An isolated nucleic acid consisting of a polynucleotide sequence encoding the amino acid sequence of SEQ ID NOs:
- 2, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 31.
An isolated nucleic acid comprising a polynucleotide sequence encoding a fusion peptide consisting of the amino acid sequence of SEQ ID NOs:
- 2, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 31 and a heterologous polypeptide.
Dependencies are inferred from the claim text.