Methods for separating soluble selenoglycoproteins
AssigneeAlltech, Inc.
InventorsStefan Kwiatkowski, Ronan Power, Clayton Matney, Paiman P. Ghoroghchian, Eric M. Ostertag
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Abstract
The invention relates to soluble selenium compositions and methods of production, separation and purification thereof. In particular the present invention provides methods of preparing water soluble selenoglycoproteins (e.g., via extracting selenoglycoproteins from selenium enriched yeast), methods of supplementing a selenium deficient composition via admixing water soluble selenoglycoproteins with the selenium deficient composition, compositions comprising the water soluble selenoglycoproteins and methods of administering the same.
Claims17
A method for preparation of soluble selenoglycoproteins comprising:
- a) providing selenium enriched yeast;
- b) exposing the selenium enriched yeast to acidic conditions followed by centrifugation to generate
- i) a pellet comprising acid insoluble material;
- and
- ii) a liquid phase comprising the extract of selenium enriched yeast soluble under the acidic conditions;
- c) precipitating selenoglycoproteins from the liquid phase comprising the extract of selenium enriched yeast soluble under the acidic conditions via raising the pH of the liquid phase;
- and
- d) separating the precipitated selenoglycoproteins from the liquid phase.
Dependencies are inferred from the claim text.