Imatinib immunoassay
AssigneeSaladax Biomedical Inc.
InventorsSalvatore J. Salamone, Jodi Blake Courtney, Alexander Volkov
Life of this patent
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Abstract
Novel conjugates and immunogens derived from imatinib and monoclonal antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of imatinib or its pharmacologically active salts in biological fluids.
Claims9
An antibody which binds selectively to imatinib and its pharmacologically active salts without having any substantial cross-reactivity with N-desmethyl imatinib.
A kit for determining the presence of imatinib or its pharmacologically active salts in a patient sample comprising reagents in separate containers, one of the reagents being a conjugate of a carrier containing a polymer having either a reactive thiol or amino group with a compound of the formula:
- or its pharmacologically active salts;
- wherein Y is an organic spacing group;
- X is a terminal functional group capable of binding to said carrier through said amino or thiol group and;
- p is an integer from 0 to 1;
- and a second reagent in a separate container being an antibody which binds selectively to imatinib and its pharmacologically active salts without having any substantial cross-reactivity with the pharmacologically inactive metabolites of imatinib.
Dependencies are inferred from the claim text.