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US 8,263,744 B2Granted
Binding proteins that bind to EpCAM linked to an effector molecule
AssigneeViventia Biotechnologies Inc.
InventorsJeannick Cizeau, Glen Christopher Macdonald
Life of this patent
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Abstract
An optimized nucleic acid sequence encoding the immunoconjugate VB6-845 is described Modifications to the original VB6-845 include changes in the nucleic acid sequence encoding the VH region, CH region, CL region, VL region, the furm linker and the bouganm toxin. The optimized VB6-845 displays improved recombinant protein expression over the original in an E. coli expression system.
Claims8
An isolated binding protein comprising a heavy chain and a light chain encoded by a nucleic acid molecule comprising a VH region shown in SEQ ID NO:11, a CH region shown in SEQ ID NO:13;
- a VL region shown in SEQ ID NO:15;
- and a CL region shown in SEQ ID NO:17.
Dependencies are inferred from the claim text.