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US 8,263,736 B2Granted
Compounds and their effects on feeding behaviour
AssigneeImperial Innovations Limited
InventorStephen Robert Bloom
Life of this patent
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Abstract
The invention provides a compound of formula (I): X-PYY* (3-36) (I) wherein X is selected from H, PYY1-2 (ie Tyr Pro) and D-Allo-Ue; PYY*(3-36) representing PYY (3-36) in which one or more residues is replaced by an acylated lysine group, the acyl group being selected from: CO—C1-20 alkyl, CO—C2-20 alkenyl, CO—C5-10 aryl and CO—C5-10 ar-C1-20 alkyl; a variant or derivative thereof; or a salt or solvate thereof. The compounds are effective in inducing satiety and suppressing appetite and they are thus useful in treating various diseases, including obesity.
Claims21
A compound of formula (I):
- PYY3-36Lys12-Acyl (I)
- wherein Acyl is an acyl group selected from the group consisting of CO—C1-20alkyl, CO—C2-20alkenyl, CO—C5-10 aryl, and CO—C5-10aryl-C1-20alkyl;
- or a derivative thereof;
- wherein the derivative is the compound of formula (I) that is modified by one or more processes selected from the group consisting of amidation, glycosylation, carbamylation, sulfation, phosphorylation, cyclization, lipidization, and pegylation;
- or a salt or solvate thereof.
2 more elements
Dependencies are inferred from the claim text.