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US 8,263,704 B2Granted
Bioabsorbable surgical composition
AssigneeTyco Healthcare Group LP
InventorsJoshua B. Stopek, Ahmad Robert Hadba
Life of this patent
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Abstract
Bioabsorbable macromer compositions are provided including a polymeric component possessing a lipid segment which enhances the affinity of the macromer composition to targeted tissue. In some embodiments, the polymeric component can be combined with a second component. The resulting bioabsorbable macromer composition can be employed as an adhesive or sealant for medical/surgical uses.
Claims19
A bioabsorbable macromer composition of the formula selected from the group consisting of
- R1-[A]v-R2—R3 (IV)
- and
- R3—R2-[A]vR1-[A]v-R2—R3 (V)
- wherein R1 comprises a lipid segment selected from the group consisting of phosphoryl choline, phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl inositol, phosphatidyl glycerol, phosphatidyl serine, phosphatidic acid, lysophosphatidyl choline, lysophosphatidyl ethanolamine, lysophosphatidyl glycerol, lysophosphatidyl serine, lysophosphatidic acid, PEG-phosphatidylethanolamine, PVP-phosphatidylethanolamine, sphingosine, aminosphingosine, and combinations thereof, R2 comprises a polymer selected from the group consisting of polysaccharides and polyols, R3 comprises a functional component selected from the group consisting of isocyanates, succinimides, aldehydes, and combinations thereof, A is a bioabsorbable group, and v is a number from about 1 to about 20.
1 more element
A bioabsorbable macromer composition comprising:
- a polymeric component of the formula
- R3—R2-[A]v-R1-[A]v-R2—R3 (V)
- wherein R1 comprises a lipid segment selected from the group consisting of phosphoryl choline, phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl inositol, phosphatidyl glycerol, phosphatidyl serine, phosphatidic acid, lysophosphatidyl choline, lysophosphatidyl ethanolamine, lysophosphatidyl glycerol, lysophosphatidyl serine, lysophosphatidic acid, PEG-phosphatidylethanolamine, PVP-phosphatidylethanolamine, sphingosine, aminosphingosine, and combinations thereof, R2 comprises a polymer selected from the group consisting of polysaccharides and polyols, R3 comprises a functional component selected from the group consisting of isocyanates, succinimides, aldehydes, and combinations thereof, A is a bioabsorbable group, and v is a number from about 1 to about 20;
- and
- a second component possessing at least one group reactive with the functional component on the polymeric compound.
2 more elements
Dependencies are inferred from the claim text.