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US 8,263,679 B2Granted
Prepolymers with dangling polysiloxane-containing polymer chains
AssigneeNovartis AG
InventorsJian S. Zhou, Dawn A. Smith
Life of this patent
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Abstract
The invention provide a new class of silicone-containing prepolymers containing dangling polysiloxane-containing polymer chains. This class of silicone-containing prepolymer is capable of being actinically crosslinked to form a silicone hydrogel material with a relatively high oxygen permeability, a reduced elastic modulus, and a relatively high ion permeability. The present invention is also related to silicone hydrogel contact lenses made from this class of silicone-containing prepolymers and to methods for making the silicone hydrogel contact lenses.
Claims9
A soft contact lens, comprising:
- a silicone hydrogel material that is obtained by curing a lens-forming material in a mold, wherein the lens-forming material comprises at least one actinically crosslinkable prepolymer and is substantially free of vinylic monomers and crosslinking agent with molecular weight of less than 1500 dalton, wherein the prepolymer comprises (1) dangling polysiloxane units derived from one or more monoethylenically functionalized polysiloxane-containing monomers and/or one or more monoethylenically-functionalized polysiloxane-containing macromers, wherein the dangling polysiloxane units is free of ethylenically unsaturated groups;
- (2) hydrophilic units derived from one or more hydrophilic vinylic monomers;
- (3) crosslinking units derived from at least one polysiloxane-containing crosslinker which comprises two or more ethylenically unsaturated groups and a moiety of
- in which R1 and R2 are independently a monovalent C1-C10 alkyl, C1-C10 ether, C1-C10 fluoroalkyl, C1-C10 fluoroether, or C6-C18 aryl radical, which may comprise hydroxy group, primary, secondary, or tertiary amine group, carboxy group, or carboxylic acid;
- n is an integer of 4 or higher;
- (4) multiple ethylenically unsaturated groups;
- and (5) optionally hydrophobic units derived from at least one hydrophobic vinylic monomer.
4 more elements
Dependencies are inferred from the claim text.