Polymeric micelles for drug delivery

A drug-loaded micelle comprising a triblock copolymer, wherein said micelle has a drug-loaded inner core, a crosslinked outer core, and a hydrophilic shell, wherein the multiblock copolymer is of formula III:

• wherein:
• n is 10-2500;
• m is 5-50;
• m′ is 5-50;
• L is a metal crosslinked amino acid side-chain group;
• Ry is a hydrophobic or ionic, natural or unnatural amino acid side-chain group;
• R1 is —Z(CH2CH2Y)p(CH2)tR3, wherein:
• Z is —O—;
• Y is —O—;
• p is 0-10;
• t is 0-10;
• and
• R3 is optionally substituted aliphatic group;
• Q is a valence bond;
• R2a is —NR4C(O)R4;
• and
• each R4 is independently hydrogen or an optionally substituted aliphatic.