Methods for treatment of renal failure
AssigneesTechnion Research & Development Foundation Limited, Rappaport Family Institute
InventorsOfer Binah, Zaid A. Abassi, Moussa B. H. Youdim, Yaron Barac
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Abstract
Propargylamine, propargylamine derivatives N-propargyl-1-aminoindan and analogs thereof, and pharmaceutically acceptable salts thereof, are useful for administration to a subject at high risk for or suffering from acute renal failure (ARF).
Claims12
A method for treatment of a person diagnosed as suffering from acute renal failure, which comprises
- administering to the person an effective amount therefor of S-(−)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof.
A method for treatment of a subject diagnosed as being susceptible to acute renal failure which comprises
- administering to the subject an effective amount therefor of S-(−)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof,
- wherein said subject susceptible to acute renal failure is a subject exposed to (i) a therapeutic agent selected from the group consisting of cyclosporines, aminoglycosides, nonsteroidal antiinflammatory drugs, cisplatin and amphotericin B;
- (ii) contrast agents;
- or (iii) heavy metals or organic solvents.
A method for improving the function of an ischemic kidney in a subject suffering from acute renal failure, which comprises administering to the subject an effective amount therefor of S-(−)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof.
A method for improving the function of a kidney in a subject diagnosed as being susceptible to acute renal failure, which comprises administering to the subject an effective amount therefor of S-(−)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof,
- wherein said subject susceptible to acute renal failure is a subject exposed to (i) a therapeutic agent selected from the group consisting of cyclosporines, aminoglycosides, nonsteroidal antiinflammatory drugs, cisplatin and amphotericin B;
- (ii) contrast agents;
- or (iii) heavy metals or organic solvents.
A method for attenuating deterioration of kidney function in a subject diagnosed as being susceptible to acute renal failure, which comprises administering to the subject an effective amount therefor of S-(−)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof,
- wherein said subject susceptible to acute renal failure is a subject exposed to (i) a therapeutic agent selected from the group consisting of cyclosporines, aminoglycosides, nonsteroidal antiinflammatory drugs, cisplatin and amphotericin B;
- (ii) contrast agents;
- or (iii) heavy metals or organic solvents.
Dependencies are inferred from the claim text.