Microbiologically sound and stable solutions of gamma-hydroxybutyrate salt for the treatment of narcolepsy
AssigneeJazz Pharmaceuticals, Inc.
InventorsHarry Cook, Martha Hamilton, Douglas Danielson, Colette Goderstad, Dayton T. Reardan
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Abstract
Disclosed are formulations of gamma-hydroxybutyrate in an aqueous medium that are resistant to microbial growth. Also disclosed are formulations of gammahydroxybutyrate that are also resistant to the conversion into GBL. Disclosed are methods to treat sleep disorders, including narcolepsy, with these stable formulations of GHB. The present invention also provides methods to treat alcohol and opiate withdrawal, reduced levels of growth hormone, increased intracranial pressure, and physical pain in a patient.
Claims18
A pharmaceutical composition, comprising an aqueous solution of about 500 mg/ml sodium gamma-hydroxybutyrate, wherein the composition has a pH of about 7.3 to about 8.5, wherein the composition is chemically stable and resistant to microbial growth, and wherein the composition is free of preservatives.
Dependencies are inferred from the claim text.