Antimicrobial compounds and methods of use thereof
AssigneeVanderbilt University
InventorsEric Skaar, Devin Stauff, Olusegun O. Aranmolate
Life of this patent
Estimating the term…
Abstract
In one aspect, the invention relates to compounds and methods useful for activating heme sensor systems; for decreasing virulence of bacteria, for example, Staphylococcus aureus; pharmaceutical compositions comprising the compounds; and methods of treating microbial-related disorders. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Claims19
A method for activating a heme sensor system in at least one bacterium comprising the step of contacting the at least one bacterium with an effective amount of a compound selected from the following compounds,
- thereby activating a heme efflux pump (HrtAB) in the at least one bacterium.
A method for treating a bacterial infection in a mammal comprising the step of administering a therapeutically effective amount of a compound selected from the following compounds,
- thereby decreasing bacterial virulence in the mammal.
Dependencies are inferred from the claim text.