Back to results
US 8,263,640 B2Granted
Inhibitors of fatty acid uptake and methods of use
AssigneeNUtech Ventures
InventorsConcetta Dirusso, Paul Black
Life of this patent
Estimating the term…
Abstract
The present disclosure describes inhibitors of fatty acid uptake and methods of using such inhibitors. Specifically, the present disclosure describes inhibitors with specificity for FATP2.
Claims17
A method of inhibiting fatty acid uptake by cells, comprising:
- contacting said cells with a compound of Formula (IV):
- or a pharmaceutically acceptable salt form thereof, wherein:
- R1 and R2 are independently selected from the group consisting of:
- H, F, Cl, Br, I, OH, and O(C1-6 alkyl).
1 more element
A method of inhibiting fatty acid uptake by cells, comprising:
- contacting said cells with a compound selected from the group consisting of:
- or a pharmaceutically acceptable salt form thereof.
A method of treating a disease associated with dyslipidemias and lipotoxicity in an individual in need thereof, comprising:
- administering, to the individual, a compound of Formula (IV):
- or a pharmaceutically acceptable salt form thereof, wherein:
- R1 and R2 are independently selected from the group consisting of:
- H, F, Cl, Br, I, OH, and O(C1-6 alkyl).
1 more element
A method of treating a disease associated with dyslipidemias and lipotoxicity in an individual in need thereof, comprising:
- Administering, to the individual, a compound selected from the group consisting of:
- or a pharmaceutically acceptable salt form thereof.
A method of inhibiting FATP2 in a cell, the method comprising:
- contacting said cell with a compound of Formula (IV):
- or a pharmaceutically acceptable salt form thereof, wherein:
- R1 and R2 are independently selected from the group consisting of:
- H, F, Cl, Br, I, OH, and O(C1-6 alkyl).
1 more element
Dependencies are inferred from the claim text.