1,2,3-triazoles as 11-beta hydroxysteroid dehydrogenase type I inhibitors

A compound of formula (I)

• or salts thereof wherein:
• R1 is aryl or bicycloalkyl, both of which may be optionally substituted with one or more R1as;
• R1a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, halo, —NH2, —CN, —C(═O)OH, —C(═O)OR14, —OCF3, —OR10, —OH, —OCF3, —SH, —SR14, —C(═O)NR14R14, —NR14R14, —C(═O)R14, —NR14C(═O)R14, —OC(═O)R14, —C(═NR14)NR14R14, —NHC(═NR14)NR14R14, —S(═O)R14, —NR14C(═O)OR10, —OC(═O)NR14R14, —NR14C(═O)NR14R14 or arylalkyl, wherein the alkyl, aryl, cycloalkyl, cycloalkylalkyl, heterocyclyl, and heterocyclylalkyl may be optionally substituted with 0-3 R10a;
• R2 is unsubstituted C1-4 alkyl;
• R3 is bicycloalkyl, which may be optionally substituted with one or more R3a's;
• R3a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, halo, —NH2, —CN, —NO2, —C(═O)OH, —C(═O)OR14, —OCF3, —OR10, —OH, —OCF3, —SH, —SR14, —C(═O)NR14R14, —NR14R14, —S(O)2NR14R14, —NR14S(O)2CF3, —C(═O)NR14S(O)2R10, —S(O)2NR14C(═O)OR10, —S(O)2NR14C(═O)NR14R14, —C(═O)NR14S(O)2R14, —C(═O)R14, —NR14C(═O)R14, —OC(═O)R14, —C(═NR14)NR14R14, —NHC(═NR14)NR14R14, —S(═O)R14, —S(O)2R14, —OS(O)2R14, —NR14C(═O)OR10, —NR14S(O2)R8, —OC(═O)NR14R14, —NR14C(═O)NR14R14 or arylalkyl, wherein the alkyl, aryl, cycloalkyl, cycloalkylalkyl, heterocyclyl, and heterocyclylalkyl may be optionally substituted with 0-3 R10a;
• R8, at each occurrence, is independently alkyl, aryl or heterocyclyl;
• R10, at each occurrence, is independently selected from alkyl, cycloalkyl, alkenyl, alkynyl, aryl, arylalkyl or heterocyclyl, wherein the alkyl, cycloalkyl, aryl, arylalkyl or heterocyclyl may be optionally substituted with 0-3 R10a, and the heterocyclyl contains 1-4 heteroatoms selected from N, O, and S;
• R10a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, halo, —NH2, —CN, —NO2, —OCF3, —OR14, —OH, —SH, —SR14, —C(═O)NR14R14, —NR14R14, —S(O)2NR14R14, —NR14S(O)2CF3, —C(═O)NR14S(O)2R14, —S(O)2NR14C(═O)OR14, —S(O)2NR14C(═O)NR14R14, —C(═O)NR14S(O)2CF3, —C(═O)R14, —NR14C(═O)R14, —OC(═O)R14, —C(═NR14)NR14R14, —NHC(═NR14)NR14R14, —S(═O)R14, —S(O)2R14, —NR14C(═O)OR8, —NR14S(O2)R8 or arylalkyl;
• R14, at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl, aryl or arylalkyl, wherein the alkyl, cycloalkyl, aryl or arylalkyl may be optionally substituted with 0-3 R14a;
• R14a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, halo, —NH2, —NO2, —C(═O)OH, —C(═O)OR15, —OCF3, —OR15, —OH, —SH, —SR15, —C(═O)NR15R15, —NR15R15, —S(O)2NR15R15, —NR15S(O)2CF3, —C(═O)NR15S(O)2R15, —S(O)2NR15C(═O)OR15, —S(O)2NR15C(═O)NR15R15, —C(═O)NR15S(O)2CF3, —C(═O)R15, —NR15C(═O)R15, —OC(═O)R15, —C(═)R15, —NR15R15, —NHC(═NR15)NR15R15, —S(═O)R15, —S(O)2R15, —NR15C(═O)OR8, —NR15S(O2)R8 or arylalkyl;
• and
• R15, at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl, aryl or arylalkyl;
• provided that:
• the compound is not a compound of the following structure: