Aryl-substituted heterocycles, and use thereof

A compound of the formula

• in which
• E represents a group of the formula
• where
• R1 represents hydrogen, hydroxy, amino, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-alkylamino, C3-C6-cycloalkyl, C3-C6-cycloalkyloxy, C3-C6-cycloalkylamino, C1-C4-alkylcarbonylamino or C1-C4-alkoxycarbonylamino,
• where
• alkyl, alkoxy, alkylamino may be substituted by a substituent, the substituent being selected from the group consisting of hydroxy, amino, C1-C4-alkoxy, C1-C4-alkylamino, C3-C6-cycloalkylamino and a 4- to 7-membered saturated heterocyclyl bound via an N atom which may contain a ring member from the group consisting of N—R5 or O,
• where
• R5 represents hydrogen or C1-C4-alkyl,
• and
• R10 represents hydrogen, C1-C4-alkyl, C1-C4-alkoxy, C3-C6-cycloalkyl, C3-C6-cycloalkyloxy or —NR11R12,
• where
• R11 represents C1-C4-alkyl or C3-C6-cycloalkyl,
• and
• R12 represents C1-C4-alkyl,
• A represents a 5-membered heteroaryl or partially unsaturated 5-membered heterocyclyl,
• where heteroaryl and heterocyclyl are attached in the 1- or 2-position to the phenyl ring and heteroaryl and heterocyclyl for their part have a 1,3-attachment to the phenyl ring and the carbonylaminomethyl group,
• and
• where heteroaryl and heterocyclyl are substituted by a substituent R6,
• where R6 is attached to the neighbouring atom of the atom to which the carbonylaminomethyl group is attached and has a 1,4-attachment to the phenyl ring
• and
• where the atom to which R6 is attached is a nitrogen or carbon atom
• and
• where
• R6 represents phenyl or a 5- or 6-membered heteroaryl, where phenyl and heteroaryl may be substituted by 1 to 3 substituents, where the substituents independently of one another are selected from the group consisting of halogen, hydroxy, hydroxymethyl, hydroxyethyl, amino, aminomethyl, aminoethyl, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-alkoxymethyl, C1-C4-alkylamino, C1-C4-alkylaminomethyl, hydroxycarbonyl, hydroxy-carbonylmethyl, aminocarbonyl, aminocarbonylmethyl, C1-C4-alkoxycarbonyl, C1-C4-alkoxycarbonylmethyl, C1-C4-alkylaminocarbonyl, C1-C4-alkylaminocarbonylmethyl, aminosulphonyl, C1-C4-alkylaminosulphonyl and C1-C4-alkylsulphonyl,
• R2 represents hydrogen, fluorine, chlorine, cyano, hydroxy, amino, trifluoromethyl, trifluoromethoxy, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-alkoxymethyl, C1-C4-alkylamino, C3-C6-cycloalkyl, aminocarbonyl, C1-C4-alkoxycarbonyl or C1-C4-alkylaminocarbonyl,
• R3 represents hydrogen, fluorine, chlorine, cyano, hydroxy, amino, trifluoromethyl, trifluoromethoxy, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-alkoxymethyl, C1-C4-alkylamino, C3-C6-cycloalkyl, aminocarbonyl, C1-C4-alkoxycarbonyl or C1-C4-alkylaminocarbonyl,
• R4 represents a group of the formula
• where
• * is the point of attachment to the carbonyl group,
• R7 represents hydrogen, fluorine, chlorine, cyano, ethynyl, C1-C4-alkyl, C1-C4-alkoxy or C3-C6-cycloalkyl,
• R8 represents hydrogen, amino, C1-C4-alkyl, C1-C4-alkylamino or C3-C6-cycloalkyl,
• and
• R9 represents hydrogen, fluorine, chlorine, amino or C1-C4-alkyl,
• or one of its salts, its solvates or the solvates of its salts.