Triazol derivatives useful for the treatment of diseases
AssigneePfizer Inc.
InventorsLyn Howard Jones, Dannielle Frances Roberts, Ross Sinclair Strang
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Abstract
The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
Claims18
A compound of formula (1),
- wherein:
- A is selected from:
- wherein * is the attachment point of A to the carbon bearing the hydroxy;
- X is —(CH2)m— where m is 7 to 12;
- or
- X is:
- Y is selected from
- wherein ** and *** are the attachment points, ** being linked to X;
- n is 0 or 1;
- R1 is selected from cyclopentyl, cyclohexyl, phenyl, furanyl and thiophenyl;
- and
- R2 is selected from phenyl, furanyl and thiophenyl;
- or a pharmaceutically acceptable salt thereof.
5-[(1R)-2-{[2-(4-{2-[4-({3-[(R)-cyclohexyl(hydroxy)phenylmethyl]-1H-1,2,4-triazol-1-yl}methyl)piperidin-1-yl]ethyl}phenyl)ethyl]amino}-1-hydroxyethyl]-8-hydroxyquinolin-2(1H)-one, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.