Fused-ring derivative and medical application of same

A fused ring derivative represented by the formula:

• wherein
• X1 and X2 independently represent CH or N;
• ring U represents C6 aryl or 5 or 6-membered heteroaryl;
• m represents an integral number from 0 to 2;
• n represents an integral number from 0 to 3;
• R1 represents a hydroxy group, a halogen atom, amino or C1-6 alkyl, and when m is 2, two R1 are optionally different from each other;
• R2 represents any of (1) to (11):
• (1) a halogen atom;
• (2) a hydroxy group;
• (3) cyano;
• (4) nitro;
• (5) carboxy;
• (6) carbamoyl;
• (7) amino;
• (8) C1-6 alkyl, C2-6 alkenyl or C1-6 alkoxy each of which may independently have any group selected from substituent group a;
• (9) C2-6 alkynyl, C1-6 alkylsulfonyl, mono(di)C1-6 alkylsulfamoyl, C2-7 acyl, C1-6 alkoxycarbonyl, C1-6 alkoxycarbonyloxy, mono(di)C1-6 alkylamino, mono(di)C1-6 alkoxy C1-6 alkylamino, C1-6 alkoxy C1-6 alkyl(C1-6 alkyl)amino, C2-7 acylamino, C1-6 alkoxycarbonylamino, C1-6 alkoxycarbonyl(C1-6 alkyl)amino, mono(di)C1-6 alkylcarbamoyl, mono(di)C1-6 alkoxy C1-6 alkylcarbamoyl, C1-6 alkoxy C1-6 alkyl(C1-6 alkyl)carbamoyl, mono(di)C1-6 alkylaminocarbonylamino, C1-6 alkylsulfonylamino or C1-6 alkylthio;
• (10) C3-8 cycloalkyl, 3 to 8-membered heterocycloalkyl, C5-8 cycloalkenyl or 5 to 8-membered heterocycloalkenyl;
• (11) C6 aryl, C6 aryloxy, C6 arylcarbonyl, 5 or 6-membered heteroaryl, 5 or 6-membered heteroaryloxy, 5 or 6-membered heteroarylcarbonyl, C6 arylamino, C6 aryl(C1-6 alkyl)amino, 5 or 6-membered heteroarylamino or 5 or 6-membered heteroaryl(C1-6 alkyl)amino;
• and when n is 2 or 3, these R2 are optionally different from each other, and when two R2 bound to the neighboring atoms exist and independently represent C1-6 alkyl or C1-6 alkoxy each of which may have C1-6 alkoxy, these two R2 optionally form a 5 to 8-membered ring together with the binding atoms;
• substituent group a consists of a fluorine atom, a hydroxy group, amino, carboxy, C1-6 alkoxy, mono(di)C1-6 alkylamino, mono(di)C1-6 alkoxy alkylamino, C1-6 alkoxy C1-6 alkyl(C1-6 alkyl)amino, C1-6 alkoxycarbonylamino, C2-7 acyl, C1-6 alkoxycarbonyl, mono(di)C1-6 alkylcarbamoyl, mono(di)C1-6 alkoxy C1-6 alkylcarbamoyl, C1-6 alkoxy C1-6 alkyl(C1-6 alkyl)carbamoyl, C1-6 alkylsulfonylamino, C2-7 acylamino, C1-6 alkoxycarbonylamino, C3-8 cycloalkyl, 3 to 8-membered heterocycloalkyl, C6 aryl and 5 or 6-membered heteroaryl,
• and wherein the formula contains one or more groups selected from the group consisting of a hydroxy group and an amino group substituted by:
• C1-6 alkyl-CO—;
• C6 aryl-CO—;
• C1-6 alkyl-O—C1-6 alkylene-CO—;
• C1-6 alkyl-OCO—C1-6 alkylene-CO—;
• C1-6 alkyl-OCO—;
• C1-6 alkyl-O—C1-6 alkylene-OCO—;
• C1-6 alkyl-COO—C1-6 alkylene;
• C1-6 alkyl-OCOO—C1-6;
• C3-8 cycloalkyl-OCOO—C1-6 alkylene;
• and a carboxy group substituted by
• C1-6 alkyl;
• C1-6 alkyl-COO—C1-6 alkylene;
• C1-6 alkyl-OCOO—C1-6 alkylene;
• and
• C3-8 cycloalkyl-OCOO—C1-6 alkylene,
• or a pharmaceutically acceptable salt thereof.