Hydrochloride salt of an azabicyclo[3.2.1]octane derivative
AssigneeNeuroSearch A/S
InventorsTrevor John Grinter, Peter Moldt, Frank Watjen
Life of this patent
Estimating the term…
Abstract
The invention relates to a hydrochloride salt of (1R,2R,3S,5S)-3-(3,4-dichlorophenyl)-2-[(methyloxy)methyl]-8-azabicyclo[3.2.1]octane, uses of the salt as a medicament in the treatment inter alia of disorders of the central nervous system and pharmaceutical compositions and dosage forms comprising the salt.
Claims14
A crystalline anhydrate hydrochloride salt of (1R,2R,3S,5S)-2-methoxymethyl-3-(3,4-dichlorophenyl)-8-azabicyclo[3.2.1]octane, which salt has the crystal structure characterized by the following XRPD peak list:
- Position
- d-spacing
- (±0.2 °2theta)
- (Angstroms)
- 6.2
- 14.2
- 12.5
- 7.1
- 13.5
- 6.6
- 15.6
- 5.7
- 18.7
- 4.8.
A crystalline anhydrate hydrochloride salt of (1R,2R,3S,5S)-2-methoxymethyl-3-(3,4-dichlorophenyl)-8-azabicyclo[3.2.1]octane, having the crystal structure characterized by a melting endotherm with an onset of 211±3° C. in the DSC thermogram.
A crystalline anhydrate hydrochloride salt of (1R,2R,3S,5S)-2-methoxymethyl-3-(3,4-dichlorophenyl)-8-azabicyclo[3.2.1]octane, having the crystal structure characterized by the following absorption peaks in the infrared spectrum of the solid product at 2858, 2767, 2715, 2581, 2503, 1472, 1411, 1368, 1272, 1191, 1137, 1125, 1090, 1058, 1028, 927, 914, 906, 879, 820, 808, 782, 706, 692 and 669±4 cm−1.
A crystalline anhydrate hydrochloride salt of (1R,2R,3S,5S)-2-methoxymethyl-3-(3,4-dichlorophenyl)-8-azabicyclo[3.2.1]octane, having the crystal structure characterized by the following peaks in the Raman spectrum at 3072, 2994, 2980, 2965, 2935, 2905, 2870, 1592, 1462, 1442, 1210, 1028, 907, 880, 820, 670, 530, 486, 460, 432, 395, 318, 240, 201, 171, 143, 94 and 68±4 cm−1.
Dependencies are inferred from the claim text.