Substituted imidazolyl-5,6-dihydrobenzo[N]isoquinoline compounds

A compound having the formula I:

• or a salt thereof, wherein:
• Rc1 is H, halogen, unsubstituted or substituted C1-C6 alkyl, unsubstituted or substituted phenyl, or unsubstituted or substituted heteroaryl comprising one or two 5- or 6-member ring and 1-4 heteroatoms selected from N, O and S;
• Rc2 is H, or unsubstituted or substituted C1-C6 alkyl;
• Rc3 and Rc4 are each independently H, unsubstituted or substituted C1-C6 alkyl, or Rc3 and Rc4, together with the atoms they attach to, form a 5-, 6- or 7-member ring which optionally comprises 1-4 heteroatoms selected from N, O and S and is optionally substituted;
• X1-X2 is CHRc6—NRy;
• Rc6 is H, unsubstituted or substituted C1-C6 alkyl, or unsubstituted or substituted C6-C10 aryl;
• Ry is H, unsubstituted or substituted C6-C10 aryl, unsubstituted or substituted heteroaryl comprising one or two 5- or 6-member ring and 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C3-C8 carbocycle, unsubstituted or substituted heterocycle comprising one or two 5- or 6-member ring and 1-4 heteroatoms selected from N, O and S, —S(O)2R1, —C(O)R1, —C(O)OR1, —(CH2)oR1, —C(═NH)NR2R2′, —C(O)NR2R2′, or —C(S)NR2R2′;
• o is 0, 1, 2, 3, or 4;
• R1 is H, unsubstituted or substituted C1-C6 alkyl, or -Ty1-Qy1;
• R2 and R2′ are each independently H, unsubstituted or substituted C1-C6 alkyl, -Ty3-Qy3, or R2 and R2′, together with the atom they attach to, form a 5-, 6- or 7-member ring which comprises 1-4 heteroatoms selected from N, O and S and is optionally substituted;
• Ty1 and Ty3 are each independently a bond, or unsubstituted or substituted C1-C6 alkyl linker;
• Qy1 is H, unsubstituted or substituted C6-C10 aryl, unsubstituted or substituted heteroaryl comprising one or two 5- or 6-member ring and 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C3-C8 carbocycle, unsubstituted or substituted heterocycle comprising one or two 5- or 6-member ring and 1-4 heteroatoms selected from N, O and S, —C(O)OR21, —C(O)R21, —C(O)NR21R21′, or —NR21R21′;
• Qy3 is H, unsubstituted or substituted C6-C10 aryl, unsubstituted or substituted heteroaryl comprising one or two 5- or 6-member ring and 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C3-C8 carbocycle, unsubstituted or substituted heterocycle comprising one or two 5- or 6-member ring and 1-4 heteroatoms selected from N, O and S, —C(O)OR31, —C(O)R31, —C(O)NR31R31′, or —NR31R31′;
• and
• R21, R21′, R31 and R31′ are each independently H, unsubstituted or substituted C1-C6 alkyl, unsubstituted or substituted C6-C10 aryl, or unsubstituted or substituted heteroaryl comprising one or two 5- or 6-member ring and 1-4 heteroatoms selected from N, O and S.