Spiro-oxindole compounds and their use as therapeutic agents

A compound of formula (I):

• wherein:
• n is 1 or 2;
• one of J and K is —CH2— and the other is —O—;
• or both J and K are each —CH2—;
• R1 is methyl, cyclopropyl, carboxymethyl, (3-carboxy)benzyl, (3-methylsulfonylamino)benzyl, [(3-methylsulfonylamino)pyridin-2-yl]methyl, [(3-carboxy)pyridin-2-yl]methyl, [(ethoxy)carbonyl]methyl, 2-cyclopropylethyl, 1,3-thiazol-5-ylmethyl, 3-methoxypropyl, (6-methylpyridin-2-yl)methyl, pyridin-3-ylmethyl, [3-(cyano)pyridine-2-yl]methyl, [3-(difluoromethyl)pyridin-2-yl]methyl, 3-(5-methyl-1,2,4-oxadiazol-3-yl)benzyl, 4-(5-methyl-1,2,4-oxadiazol-3-yl)benzyl, [5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]methyl, [5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]methyl, [4-(trifluoromethyl)pyridin-2-yl]methyl, (4-methyl-1,2,5-oxadiazol-3-yl)methyl, pyrazin-2-ylmethyl, pyrimidin-2-ylmethyl, (1-methyl-1H-benzotriazol-5-yl)methyl, [2-(tert-butoxycarbonylamino)pyridin-5-yl]methyl, [6-(dimethylamino)pyridin-3-yl]methyl, [6-(dimethylamino)pyridin-2-yl]methyl, {6-[(diphenylmethylidene)amino]pyridin-2-yl}methyl, (5-morpholin-4-ylpyridin-2-yl)methyl, [5-(dimethylamino)pyridin-2-yl]methyl, (6-aminopyridin-2-yl)methyl, (6-oxo-1,6-dihydropyridin-3-yl)methyl, (2-hydroxypyrimidin-5-yl)methyl, (1-methyl-6-oxo-1,6-dihydropyridin-3-yl)methyl, (6-aminopyridin-3-yl)methyl, [1,2,4]triazolo[1,5-a]pyridin-6-ylmethyl, (5-hydroxypyridin-2-yl)methyl, (5-bromopyridin-2-yl)methyl, hydrazinocarbonylmethyl, [6-deoxy-D-galactopyranose]-6-yl, (6-morpholin-4-ylpyridin-3-yl)methyl, [3-(methylsulfonyl)pyridin-2-yl]methyl, (4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl, (3-bromopyridin-2-yl)methyl, [(2-imidoformamido)pyridine-5-yl]methyl, (6-cyanopyridin-2-yl)methyl, (6-aminocarbonylpyridin-2-yl)methyl, diphenylmethyl, 4-methoxybenzyl, 2-(fluoromethyl)benzyl, 2-ethoxyethyl, 4-fluorophenyl, (2-fluorophenylaminocarbonyl)methyl, 2-(2-methoxyethoxy)ethyl, 4-isoxazol-5-ylbenzyl, 3-(benzyloxy)propyl, (2S)-2,3-dihydroxypropyl, 4-methoxybutyl, pentyl, isopentyl, hexyl, 3-nitrobenzyl, [3-(trifluoromethyl)pyridin-2-yl]methyl, [5-(trifluoromethyl)pyridin-2-yl]methyl, [(tert-butoxycarbonylamino)pyridin-2-yl]methyl, (3-(trifluoromethyl)pyridin-2-yl)methyl, (5-(trifluoromethyl)furan-2-yl)methyl, tetrahydrofuran-2-ylmethyl, 3-methylbutyl, cyanomethyl, 4-hydroxybenzyl, 3-cyanobenzyl, 4-fluoro-3-methoxybenzyl, 4-cyanobenzyl, [6-(trifluoromethyl)pyridin-3-yl]methyl, [4-(trifluoromethyl)-1,3-thiazol-2-yl]methyl, (3-fluoropyridin-2-yl)methyl, (4-fluoropyridin-2-yl)methyl, (5-fluoropyridin-3-yl)methyl, (5-fluoropyridin-2-yl)methyl, (3-chloropyridin-2-yl)methyl, (3,5-difluoropyridin-2-yl)methyl, (3-pyridin-3-ylisoxazol-5-yl)methyl, (2,2-difluorocyclopropyl)methyl, 2-oxobutyl, 2,1,3-benzothiadiazol-5-ylmethyl, 2,1,3-benzoxadiazol-5-ylmethyl, 1,3-benzothiazol-2-ylmethyl, (1-methyl-1H-benzimidazol-2-yl)methyl, [2-(1-methylethyl)-1,3-thiazol-4-yl]methyl, tert-butoxycarbonyl, [1-(tert-butoxycarbonyl)piperidin-4-yl]methyl, (2-methoxypyrimidin-5-yl)methyl, (6-methoxypyridin-3-yl)methyl, (1-oxydopyridin-2-yl)methyl, (3-aminopyridin-2-yl)methyl, piperidin-4-ylmethyl, [1-(1-methylethyl)piperidin-4-yl]methyl, (1-methylpiperidin-4-yl)methyl, morpholin-2-ylmethyl, [4-(1-methylethyl)morpholin-2-yl]methyl, (4-methylmorpholin-2-yl)methyl, (2S)-morpholin-2-ylmethyl, [(2S)-4-methylmorpholin-2-yl]methyl, [5-(difluoromethyl)furan-2-yl]methyl, tetrahydro-2H-pyran-4-ylmethyl, tetrahydro-2H-pyran-2-ylmethyl, (5-chloro-1-methyl-1H-imidazol-2-yl)methyl, (6-chloropyridin-2-yl)methyl, (4,6-dimethoxypyrimidin-2-yl)methyl, [(3-methylaminocarbonyl)pyridin-2-yl]methyl, 1-[2-(aminoethyl)aminocarbonylpyridin-3-yl]methyl, pyridin-2-ylmethyl, (2R)-1,4-dioxan-2-ylmethyl, 1,4-dioxan-2-ylmethyl, 3,4-dimethoxybenzyl, 3,5-dimethoxybenzyl, 3-hydroxypropyl, 3-phthalimidopropyl, 3-aminobenzyl, (3-aminocarbonyl)benzyl, (4-aminocarbonyl)benzyl, (3-N,N-dimethylaminocarbonyl)benzyl, 4-(benzyloxy)benzy, 4-fluorobenzyl, 2,3-difluorobenzyl, 3,5-difluorobenzyl, 2-chloro-4-fluorobenzyl, [3-(2-fluorophenyl)aminocarbonyl]benzyl, 3-(methoxycarbonyl)benzyl, 4-(methoxycarbonyl)benzyl, 4-(ethoxycarbonyl)benzyl, 3-(dimethylamino-sulfonyl)benzyl, 3-(3-methyl-1,2,4-oxadiazol-5-yl)benzyl, 4-(3-amino-1H-pyrazol-5-yl)benzyl, 4-(3-methyl-1,2,4-oxadiazol-5-yl)benzyl, 3-(morpholin-4-ylsulfonyl)benzyl, 2-(difluoromethyl)benzyl, (3-trifluoromethoxy)benzyl, (2-fluoro-6-trifluoromethyl)benzyl, (2-fluoro-5-trifluoromethyl)benzyl, (2-trifluoromethoxy)benzyl, 3-(amino(hydroxyimino)methyl)benzyl, 2-amino-2-(hydroxyimino)ethyl, (6-(N′-hydroxyformimidamido)pyridin-3-yl)methyl, 2-(2,2,5-trimethyl-1,3-dioxan-2-yl)ethyl, (4-benzylmorpholin-2-yl)methyl, [(2S)-4-benzylmorpholin-2-yl]methyl, 2,3-dihydro-1,4-benzodioxin-6-ylmethyl, [5-(trifluoromethyl)furan-2-yl]methyl, 3-(trifluoromethyl)benzyl, [3-(trifluoromethyl)pyrazin-2-yl]methyl, [4-(trifluoromethyl)pyridin-3-yl]methyl, (5-methoxycarbonylfuran-2-yl)methyl, 5-carboxyfuran-2-ylmethyl, 5-(dimethylaminocarbonyl)furan-2ylmethyl, [2-(trifluoromethyl)pyridin-3-yl]methyl, methylcarbonyl, ethoxycarbonyl, tert-butoxycarbonyl or [(3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4′,5′-d]pyran-5-yl]methyl;
• each R2 is independently hydrogen, hydroxy, amino, (hexanylaminocarbonyl)amino, (cyclopentylaminocarbonyl)amino, benzylamino, (cyclohexylaminocarbonyl)amino, methylsulfonylamino, (methyl)carbonylamino, N,N-dimethylaminocarbonyl, (ethyl)carbonylamino, (butyl)carbonylamino, (tert-butyl)carbonylamino, (pentanyl)carbonylamino, (hexanyl)carbonylamino, (methoxymethyl)carbonylamino, cyclobutylcarbonylamino, [2-methoxy(ethoxymethyl)]carbonylamino, (methylsulfonyl)amino, (2-trifluoromethylphenyl)carbonylamino, (cyclohexanyl)carbonylamino, (cyclopentanyl)carbonylamino, (cyclopropanyl)carbonylamino, (phenyl)carbonylamino, bromo, cyano, fluoro, methyl, methoxy, hydroxycarbonyl, methylcarbonyl, pyrrolidinylcarbonyl, aminocarbonyl, methylaminocarbonyl, (2-methoxyethyl)aminocarbonyl, (cyclopropyl)aminocarbonyl, pentylaminocarbonyl, (cyclobutyl)aminocarbonyl, (cyclopentyl)aminocarbonyl, hexanylaminocarbonyl, (cyclohexyl)aminocarbonyl, (4-fluorophenyl)aminocarbonyl, (4-fluorobenzyl)aminocarbonyl, (pyridin-2-ylmethyl)aminocarbonyl, 2-(2-methoxyethoxy)ethoxy, [3-(trifluoromethyl)pyridin-2-yl]oxyl, quinolinyl, phenoxycarbonyl, 2-oxochromenyl, 2-oxopyrrolidinyl, morpholinyl, 2-oxopyridinyl, benzyloxyl, [3-(trifluoromethyl)pyridin-2-yl]methoxy, pyridine-2-ylmethoxy, pyridin-2-yloxy, 4-(trifluoromethyl)phenoxy, 2-methyl-1,3-thiazol-4-yl, 2-amino-1,3-thiazol-4-yl, 6-(dimethylamino)pyridin-3-yl, furan-3-yl, 1H-pyrazol-3-yl, 1H-pyrazol-4-yl, 1-methyl-1H-pyrazol-4-yl , 5-hydroxy-1H-pyrazol-3-yl, 5-methyl-1,2,4-oxadiazol-3-yl, (6-methoxypyridin-3-yl)oxy, 1,3-benzodioxol-5-yloxy, 4-fluorobenzyloxy, 3,5-dimethylisoxazol-4-yl, phenoxy, 3-methoxyphenoxy, 4-methoxyphenoxy, 3-morpholin-4-ylphenoxy, 4-fluorophenoxy, 4-methoxyphenyl or 4-phenoxyphenyl;
• or two adjacent R2's, together with the adjacent carbons to which they are attached, form a fused thiazolyl ring, a fused pyridyl ring or a fused dioxinyl ring;
• as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof;
• or a pharmaceutically acceptable salt or prodrug thereof.