Indazole compounds as CCR1 receptor antagonists

A compound of the formula (I)

• wherein
• Ar1 is heteroaryl or heterocycle each optionally substituted by one to three Ra;
• X1 is a —(CH2)n— wherein one or more hydrogen atoms can be replaced by Ra;
• X2 is Ar2, —S(O)m—Ar2 or —S(O)mNReRf or —S(O)mNH—Ar2;
• Ar2 is carbocycle, heteroaryl or heterocycle each optionally substituted by one to three Rb;
• R1 is hydrogen, C1-6 alkyl or C1-6alkoxyC1-6alkyl;
• R2, R3 are each independently hydrogen or C1-6 alkyl optionally substituted by Ra;
• Ra is C1-6 alkyl, C3-10 cycloalkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkylsulfonyl, C1-6 alkoxycarbonyl, amino, mono- or di-C1-6 alkylamino, C3-6 cycloalkylamino, C1-6 alkylaminocarbonyl, C1-6 acyl, C1-6 acylamino, C1-6 dialkylaminocarbonyl, hydroxyl, halogen, cyano, nitro, oxo, R4—S(O)m—NH—, R4—NH—S(O)m—, aryl or carboxyl;
• Rb is hydroxyl, carboxyl, halogen, —(CH2)n—CN, nitro, oxo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, C1-6 alkoxy, C1-6 alkoxycarbonyl, —(CH2)n—NRcRd, R4—S(O)m—, R4—S(O)m—NRe—, R4—NRe—S(O)m—, —NRf—C(O)—Re, —(CH2)x—C(O)—(CH2)n—NRcRd, heterocyclyl, aryl or heteroaryl, each substituent on Rb where possible is optionally halogenated or substituted with 1 to 3 C1-6 alkyl, C1-6 acyl, C1-6 alkoxycarbonyl, C1-6 alkyl-S(O)m—, aryl or carboxyl;
• each Rc, Rd are independently hydrogen, C1-6 alkyl, C1-6 acyl, C3-10 cycloalkyl, C1-6 alkoxy, hydroxyC1-6 alkyl, C1-6 alkylC1-6 alkoxy, C1-6 alkylsulfonyl, C1-6 alkoxycarbonyl or —(CH2)n—NReRf;
• each Re, Rf are independently hydrogen, C1-6 alkyl, C3-10 cycloalkyl, C1-6 alkoxy, hydroxyC1-6 alkyl or C1-6 acyl;
• R4 is hydrogen, C1-6 alkyl, heterocyclyl, aryl or heteroaryl each optionally substituted with C1-6 alkyl, C1-6 alkoxy, halogen, hydroxyl, amino, mono- or di-C1-6 alkylamino, C1-6 alkoxycarbonyl or C1-6 acylamino;
• R5 is hydrogen or Ra;
• Rx is hydrogen or halogen;
• each n, x are independently 0-3;
• each m is independently 0-2;
• or a pharmaceutically acceptable salt thereof.